منابع مشابه
Murine developmental control genes.
Various strategies have been used to isolate genes that participate in the regulation of mouse development. Gene families that have been identified on the basis of their homology to motifs within Drosophila control genes or human transcription factor genes, namely homeobox (Hox), paired-box (Pax), and POU genes, can be compared with respect to gene organization, structure, and expression patter...
متن کاملDevelopmental regulation of genes mediating murine brain glucose uptake.
We examined the molecular mechanisms that mediate the developmental increase in murine whole brain 2-deoxyglucose uptake. Northern and Western blot analyses revealed an age-dependent increase in brain GLUT-1 (endothelial cell and glial) and GLUT-3 (neuronal) membrane-spanning facilitative glucose transporter mRNA and protein concentrations. Nuclear run-on experiments revealed that these develop...
متن کاملPAX: developmental control genes in cell growth and differentiation.
Embryonic development requires the generation of undifferentiated cells and their subsequent maturation into differentiated cells with a specific function. The molecular events that determine the identity of differentiated cells are evidently complex and, despite encouraging results, remain largely unknown. The development of individual undifferentiated cells into their mature differentiated ph...
متن کاملActin genes in Xenopus and their developmental control.
The results summarized here have established the temporal and regional activation of three kinds of Xenopus actin genes. The cardiac and skeletal muscle actin genes are among the first cell-type-specific genes to be expressed in early development. The first transcripts to be synthesized by these genes appear to be correctly initiated, spliced, and at once translated into proteins. Both cardiac ...
متن کاملDistinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes
Autosomal dominant polycystic kidney disease (ADPKD) is one of the most commonly inherited renal diseases. At least two genes, PKD2 and PKD1 are implicated in the development of this disease. Our pathogenetic studies showed that the human and murine polycystic kidney disease (PKD) involves failure to switch out of a renal developmental program. We have thus undertaken a detailed comparative exp...
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ژورنال
عنوان ژورنال: Cell Biology International Reports
سال: 1990
ISSN: 0309-1651
DOI: 10.1016/0309-1651(90)90251-s